Some advice on saving for web

Could someone please help me get the output settings right for web.

I tried the image gallery and wasn't happy with the final output although I realise that it's a proofing tool rather than final output.

Should I try to get all my output in C-One or just go for a 16bit TIFF and do the other stuff in PS? (Not the preferred option).

What's the optimum size (px) these days for web viewing of images where the image is the only thing you want visible - not sharing screen with other stuff.

What's the best way/most efficient to output to a thumb and a viewable JPEG?

I know about sRGB and resolution but what about say, saturation and sharpening? Should you compensate for anything if output is to web only?

Here's another related area where some advice would be really appreciated: If I shoot a big painting, the resolution of detail - brushstrokes, canvas, imperfections adds to the overall feel of the image. If a shoot a tiny/small image with the same lens/camera and it fills the screen those details look like a relief map of the Himalayas! Can I get around that? I notice that sharpening can make a difference but what are the principles here?

Thanks for your help and by the way, the camera is a 1Ds MkII

Martin

Edit - Should've said CO4 Pro